Symbol
Name
ID

Brip1
BRCA1 interacting protein C-terminal helicase 1
MGI:2442836

Phenotype annotations related to reproductive system

Darker colors indicate more annotations

Human Phenotypes	Uterine leiomyosarcoma
Disease(s) Associated with BRIP1	Uterine leiomyosarcoma
colorectal cancer

Mouse Phenotypes

oligozoospermia

abnormal spermatogonia morphology

decreased primordial germ cell number

increased primordial germ cell apoptosis

decreased primordial germ cell proliferation

abnormal spermatogonia proliferation

decreased primary ovarian follicle number

abnormal ovary development

ovary cyst

abnormal seminiferous tubule morphology

abnormal seminiferous tubule epithelium morphology

increased Sertoli cell number

decreased testis weight

small testis

testicular atrophy

testis hypoplasia

endometrium hyperplasia

abnormal chiasmata formation

abnormal X-Y chromosome synapsis during male meiosis

decreased litter size

reduced fertility

Availability

Mouse Genotype

Brip1^{Gt(RRI409)Byg}/Brip1^{Gt(RRI409)Byg}

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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